Fig. 3. Force development in skinned single myocytes is reduced with HMW-AGEs injections. (A) Passive force at different sarcomere lengths (two-way ANOVA followed by Tukey's post hoc test) and (B) active force at sarcomere length 2.2 µm, both normalized to cross-sectional area (kN/m²) in control (n_cells=25) and HMW-AGEs group (n_cells=24) (p=0.06, parametric unpaired t-test) (C) The rate of force redevelopment (K_tr, s^-1, P=0.03, parametric unpaired t-test) in control (n_cells=17) and HMW-AGEs (n_cells=22) group. Data are expressed as mean ± SEM. * denotes P<0.05 vs control.